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KMID : 0378019710140060065
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New Medical Journal
1971 Volume.14 No. 6 p.65 ~ p.73
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Experimental Studies on Autogenous and Homogenous Transplantation of Articular Cartilage in Immature Rabbits
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Abstract
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Apart from degenerative changes induced by aging, articular cartilage is subject to destructive changes induced by various kinds of pathological processes; e. g., trauma, pyogenic arthritis,. rheumatoid arthritis, and inevitable surgical trauma when removing tumors in the vicinity of the joint. Restoration to normal status
of irrepairably damaged cartilage is cannot be expected by the physiologic process of healing. In an attempt to replace a damaged cartlage, various techniques of arthroplasty have been deviced using either vital structures like fascia lata or metal substitute including mold or replacement arthroplasty. However, arthroplasty is still in its preliminary stage for wide clinical application, for postoperative results are
often disappointing. Literatures on both experimental and clinical transplantations of articular cartilages are voluminous, but most authors used only fragments of articular cartilage including subchondral bone.
Despite the fact that articular cartilage derives its nutritional source mostly from synovial fluid, reports of successful transplantation of a whole articular cartilage, both autogenous and homogenous, are surprisingly scarce.
The purpose of this experiment was to observe histological changes of articular cartilage following total autogenous and homogenous transplantation in experimental animals. One hundred and thirty immature rabbits were divided into three groups; fifty for autogenous transplantation, fifty for. homogenous
transplantation and the remaining thirty for control. In each rabbit a femur was osteotomized at a one and a half centimeter above the epiphyseal plate, and in the first group the distal fragment was completely freed of its soft tissue attachment and blood supply and was replaced in situ, while in the second group
the distal femur was replaced with a fresh homogenous distal femoral fragment. In the control group the distal femur was fractured surgically without disturbing its blood supply and soft tissue attachment. The rabbits were sacrificed serially at the ends of second, fourth, eighth, twelfth, and sixteenth postoperative weeks, and histological specimens from articular cartilages of the distal femurs were examined.
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